A banknote that has a serial number near to the beginning of the serie (view High serial number for the reverse case). It's necessary to know the serial interval (or its estimated), because the serie can start in any number, nonetheless generally starts at 1.
These pieces often has a higher numismatic value to others at the same condition, based to the difficulty, and the value is higher as the serie is near to the start.
Currently there are no defined conditions yet to check whether a serie is low or not. However, this website provides the guideline based on Relative amount of low and high serial number, which there are four amount of pieces that define four intervals.
General Interval
The general low serial interval are pieces within all levels, from the beginning of the 4th Level and ending of the 1st Level.

This piece, identified as
bbcv10bs-da07-r7 has a serial interval
R6000001-R9000000 with
3,000,000 pieces (excluding damaged and not used). The interval for low serial number is
R6000001-R6001808 with
1808 pieces. Photograph credits: Mercadolibre: unreal86
A.- First Interval (1st Level)
The interval is based on the first level of the conditions. This level can be considered the more feasible.

This piece, identified as
bbcv100bsf-aa02-a8 has a serial interval
A44400001-A90000000 (estimated) with
45,600,000 (estimated) pieces (excluding damaged and not used). The interval for low serial number level 1 is
A44402941-A44407104 with
4164 pieces. Photograph credits: José Manuel Piñeiro
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B.- Second Interval (2nd Level)
The interval is based on the second level of the conditions (4.000 pieces for 90.000.000 issues).

This piece, identified as
bbcv10bs-eb03-l8 has a serial interval
L48000001-L90000000 with
42,000,000 pieces (excluding damaged and not used). The interval for low serial number level 2 is
L48000751-L48002833 with
2083 pieces. Photograph credits:
Numisfila
C.- Third Interval (3rd Level)
The interval is based on the third level of the conditions (1.000 pieces for 90.000.000 issues).

This piece, identified as
bbcv10bs-da07-r7 has a serial interval
R6000001-R9000000 with
3,000,000 pieces (excluding damaged and not used). The interval for low serial number level 3 is
R6000044-R6000277 with
234 pieces. Photograph credits: Mercadolibre: unreal86
D.- Fourth Interval (4th Level)
The interval is based on the fourth level of the conditions (100 pieces for 90.000.000 issues). This can be considered as the harder or least feasible.

This piece, identified as
bbcv100bsf-aa06-w8 has a serial interval
W00000001-W90000000 (estimated) with
90,000,000 (estimated) pieces (excluding damaged and not used). The interval for low serial number level 4 is
W00000001-W00000100 with
100 pieces. Photograph credits: Rodolfo Fuentes
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