A banknote that has a serial number near to the beginning of the serie (view High serial number for the reverse case). It's necessary to know the serial interval (or its estimated), because the serie can start in any number, nonetheless generally starts at 1.
These pieces often has a higher numismatic value to others at the same condition, based to the difficulty, and the value is higher as the serie is near to the start.
Currently there are no defined conditions yet to check whether a serie is low or not. However, this website provides the guideline based on Relative amount of low and high serial number, which there are four amount of pieces that define four intervals.
General Interval
The general low serial interval are pieces within all levels, from the beginning of the 4th Level and ending of the 1st Level.

This piece, identified as
bbcv10bs-fa01-a7 has a serial interval
A0000001-A9999999 with
9,999,999 pieces (excluding damaged and not used). The interval for low serial number is
A0000001-A0003312 with
3312 pieces. Photograph credits: Mercadolibre: business_paraguana
A.- First Interval (1st Level)
The interval is based on the first level of the conditions. This level can be considered the more feasible.

This piece, identified as
bbcv100bsf-aa02-a8 has a serial interval
A44400001-A90000000 (estimated) with
45,600,000 (estimated) pieces (excluding damaged and not used). The interval for low serial number level 1 is
A44402941-A44407104 with
4164 pieces. Photograph credits: José Manuel Piñeiro
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B.- Second Interval (2nd Level)
The interval is based on the second level of the conditions (4.000 pieces for 90.000.000 issues).

This piece, identified as
bbcv100bs-ea01-a8 has a serial interval
A00000001-A55000000 with
55,000,000 pieces (excluding damaged and not used). The interval for low serial number level 2 is
A00000831-A00003200 with
2370 pieces. Photograph credits: Mercadolibre: business_paraguana
C.- Third Interval (3rd Level)
The interval is based on the third level of the conditions (1.000 pieces for 90.000.000 issues).

This piece, identified as
bbcv50000bs-ab01-a8 has a serial interval
A00000001-A90000000 with
90,000,000 pieces (excluding damaged and not used). The interval for low serial number level 3 is
A00000101-A00001000 with
900 pieces. Photograph credits: Mercadolibre: business_paraguana
D.- Fourth Interval (4th Level)
The interval is based on the fourth level of the conditions (100 pieces for 90.000.000 issues). This can be considered as the harder or least feasible.

This piece, identified as
bbcv1000bs-ba01r has a serial interval
Z00000001-Z00063000 with
62,688 pieces (excluding damaged and not used). The interval for low serial number level 4 is
Z00000001-Z00000016 with
16 pieces. Photograph credits: Leonardo Ortega